Chanalyzer Pro latest update = 1.2.6.29
Chanalyzer Basic (aka Chanalyzer 4) = 4.2.2.27

I tested the USB ports on my Supermicro box with the Wi-Spy DBx and there were no issues with either version of Chanalyzer.
The software configuration was the same - Windows 7 Ultimate x64, . . . Only the hardware is different.
Could this be a system firmware or chip set issue?